Xavier Lab
Publications
   

Publications

Peer-Reviewed Publications

  1. Duerr EM, Mizukami Y, Moriichi K, Gala M, Jo WS, Kikuchi H, Xavier RJ, Chung DC. 2012. Oncogenic KRAS regulates BMP4 expression in colon cancer cell lines. Am J Physiol Gastrointest Liver Physiol. [Epub ahead of print]
  2. Gewurz BE, Towfic F, Mar JC, Shinners NP, Takasaki K, Zhao B, Cahir-McFarland ED, Quackenbush J, Xavier RJ, Kieff E. 2012. Genome-wide siRNA screen for mediators of NF-kappaB activation. Proc Natl Acad Sci U S A. [Epub ahead of print]
  3. Wei SC, Rosenberg IM, Cao Z, Huett AS, Xavier RJ, Podolsky DK. 2012. Tribbles 2 (Trib2) is a novel regulator of toll-like receptor 5 signaling. Inflamm Bowel Dis. [Epub ahead of print]
  4. Lee J, Kim HR, Quinley C, Kim J, Gonzalez-Navajas J, Xavier R, Raz E. 2012. Autophagy suppresses interleukin-1beta (IL-1beta) signaling by activation of p62 degradation via lysosomal and proteasomal pathways. J Biol Chem  287: 4033-40. PMC3281713.
  5. Ramadas RA, Roche MI, Moon JJ, Ludwig T, Xavier RJ, Medoff BD. 2011. CARMA1 Is Necessary for Optimal T Cell Responses in a Murine Model of Allergic Asthma. J Immunol 187: 6197-207. PMC3237896.
  6. O'Donnell MA, Perez-Jimenez E, Oberst A, Ng A, Massoumi R, Xavier R, Green DR, Ting AT. 2011. Caspase 8 inhibits programmed necrosis by processing CYLD. Nat Cell Biol 13: 1437-42. PMC3229661.
  7. Orvedahl A, Sumpter R, Jr., Xiao G, Ng A, Zou Z, Tang Y, Narimatsu M, Gilpin C, Sun Q, Roth M, Forst CV, Wrana JL, Zhang YE, Luby-Phelps K, Xavier RJ, Xie Y, Levine B. 2011. Image-based genome-wide siRNA screen identifies selective autophagy factors. Nature 480: 113-7. PMC3229641.
  8. Labbe C, Boucher G, Foisy S, Alikashani A, Nkwimi H, David G, Beaudoin M, Goyette P, Charron G, Xavier RJ, Rioux JD. 2011. Genome-wide expression profiling implicates a MAST3-regulated gene set in colonic mucosal inflammation of ulcerative colitis patients. Inflamm Bowel Dis.
  9. Rivas MA, Beaudoin M, Gardet A, Stevens C, Sharma Y, et al. 2011. Deep resequencing of GWAS loci identifies independent rare variants associated with inflammatory bowel disease. Nat Genet 43: 1066-73.
  10. Merquiol E, Uzi D, Mueller T, Goldenberg D, Nahmias Y, Xavier RJ, Tirosh B, Shibolet O. 2011. HCV causes chronic endoplasmic reticulum stress leading to adaptation and interference with the unfolded protein response. PLoS One 6: e24660. PMC3176279.
  11. Lindquist S, Karitkina D, Langnaese K, Posevitz-Fejfar A, Schraven B, Xavier R, Seed B, Lindquist JA. 2011. Phosphoprotein associated with glycosphingolipid-enriched microdomains differentially modulates SRC kinase activity in brain maturation. PLoS One 6: e23978. PMC3167820.
  12. Zhao Y, Alonso C, Ballester I, Song JH, Chang SY, Guleng B, Arihiro S, Murray PJ, Xavier R, Kobayashi KS, Reinecker HC. 2012. Control of NOD2 and Rip2-dependent innate immune activation by GEF-H1. Inflamm Bowel Dis  18: 603-12.
  13. Tam JM, Castro CE, Heath RJ, Mansour MK, Cardenas ML, Xavier RJ, Lang MJ, Vyas JM. 2011. Use of an optical trap for study of host-pathogen interactions for dynamic live cell imaging. J Vis Exp.
  14. Russo BC, Horzempa J, O'Dee DM, Schmitt DM, Brown MJ, Carlson PE, Jr., Xavier RJ, Nau GJ. 2011. A Francisella tularensis locus required for spermine responsiveness is necessary for virulence. Infect Immun 79: 3665-76. PMC3165480.
  15. Wang S, Villablanca EJ, De Calisto J, Gomes DC, Nguyen DD, Mizoguchi E, Kagan JC, Reinecker HC, Hacohen N, Nagler C, Xavier RJ, Rossi-Bergmann B, Chen YB, Blomhoff R, Snapper SB, Mora JR. 2011. MyD88-dependent TLR1/2 signals educate dendritic cells with gut-specific imprinting properties. J Immunol 187: 141-50. PMC3119749.
  16. Ng A and Xavier RJ. 2011. Leucine-rich repeat (LRR) proteins: integrators of pattern recognition and signaling in immunity. Autophagy 7: 1082-4.
  17. Le LP, Nielsen GP, Rosenberg AE, Thomas D, Batten JM, Deshpande V, Schwab J, Duan Z, Xavier RJ, Hornicek FJ, Iafrate AJ. 2011. Recurrent chromosomal copy number alterations in sporadic chordomas. PLoS One 6: e18846. PMC3094331.
  18. Heath RJ, Leong JM, Visegrady B, Machesky LM, Xavier RJ. 2011. Bacterial and host determinants of MAL activation upon EPEC infection: the roles of Tir, ABRA, and FLRT3. PLoS Pathog 7: e1001332. PMC3072376.
  19. Anderson CA, Boucher G, Lees CW, Franke A, D'Amato M, et al. 2011. Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47. Nat Genet 43: 246-52. PMC3084597.
  20. Rossin EJ, Lage K, Raychaudhuri S, Xavier RJ, Tatar D, Benita Y, Cotsapas C, Daly MJ. 2011. Proteins encoded in genomic regions associated with immune-mediated disease physically interact and suggest underlying biology. PLoS Genet 7: e1001273. PMC3020935.
  21. Tam JM, Castro CE, Heath RJ, Cardenas ML, Xavier RJ, Lang MJ, Vyas JM. 2010. Control and manipulation of pathogens with an optical trap for live cell imaging of intercellular interactions. PLoS One 5: e15215. PMC3013098.
  22. Kuballa P and Xavier RJ. 2010. Failure and exploitation of autophagy in human pathologies-cellular integrity between inflammation, infection, and cell survival. Semin Immunopathol 32: 319-22.
  23. Riley BE, Kaiser SE, Shaler TA, Ng AC, Hara T, Hipp MS, Lage K, Xavier RJ, Ryu KY, Taguchi K, Yamamoto M, Tanaka K, Mizushima N, Komatsu M, Kopito RR. 2010. Ubiquitin accumulation in autophagy-deficient mice is dependent on the Nrf2-mediated stress response pathway: a potential role for protein aggregation in autophagic substrate selection. J Cell Biol 191: 537-52. PMC3003313.
  24. Gardet A, Benita Y, Li C, Sands BE, Ballester I, Stevens C, Korzenik JR, Rioux JD, Daly MJ, Xavier RJ, Podolsky DK. 2010. LRRK2 is involved in the IFN-gamma response and host response to pathogens. J Immunol 185: 5577-85. PMC3156100.
  25. Hirota SA, Ng J, Lueng A, Khajah M, Parhar K, Li Y, Lam V, Potentier MS, Ng K, Bawa M, McCafferty DM, Rioux KP, Ghosh S, Xavier RJ, Colgan SP, Tschopp J, Muruve D, MacDonald JA, Beck PL. 2011. NLRP3 inflammasome plays a key role in the regulation of intestinal homeostasis. Inflamm Bowel Dis 17: 1359-72. PMC3026862.
  26. Lipinski MM, Zheng B, Lu T, Yan Z, Py BF, Ng A, Xavier RJ, Li C, Yankner BA, Scherzer CR, Yuan J. 2010. Genome-wide analysis reveals mechanisms modulating autophagy in normal brain aging and in Alzheimer's disease. Proc Natl Acad Sci U S A 107: 14164-9. PMC2922576.
  27. Yoon JC, Ng A, Kim BH, Bianco A, Xavier RJ, Elledge SJ. 2010. Wnt signaling regulates mitochondrial physiology and insulin sensitivity. Genes Dev 24: 1507-18. PMC2904941.
  28. Lipinski MM, Hoffman G, Ng A, Zhou W, Py BF, Hsu E, Liu X, Eisenberg J, Liu J, Blenis J, Xavier RJ, Yuan J. 2010. A genome-wide siRNA screen reveals multiple mTORC1 independent signaling pathways regulating autophagy under normal nutritional conditions. Dev Cell 18: 1041-52. PMC2935848.
  29. Ng AC, Eisenberg JM, Heath RJ, Huett A, Robinson CM, Nau GJ, Xavier RJ. 2011. Human leucine-rich repeat proteins: a genome-wide bioinformatic categorization and functional analysis in innate immunity. Proc Natl Acad Sci U S A 108 Suppl 1: 4631-8. PMC3063585.
  30. Cadwell K, Patel KK, Maloney NS, Liu TC, Ng AC, Storer CE, Head RD, Xavier R, Stappenbeck TS, Virgin HW. 2010. Virus-plus-susceptibility gene interaction determines Crohn's disease gene Atg16L1 phenotypes in intestine. Cell 141: 1135-45. PMC2908380.
  31. Yang C, Hornicek FJ, Wood KB, Schwab JH, Choy E, Iafrate J, Rosenberg A, Nielsen GP, Xavier RJ, Mankin H, Duan Z. 2010. Characterization and analysis of human chordoma cell lines. Spine (Phila Pa 1976) 35: 1257-64.
  32. Benita Y, Cao Z, Giallourakis C, Li C, Gardet A, Xavier RJ. 2010. Gene enrichment profiles reveal T-cell development, differentiation, and lineage-specific transcription factors including ZBTB25 as a novel NF-AT repressor. Blood 115: 5376-84. PMC2902135.
  33. McGovern DP, Gardet A, Torkvist L, Goyette P, Essers J, et al. 2010. Genome-wide association identifies multiple ulcerative colitis susceptibility loci. Nat Genet 42: 332-7. PMC3087600.
  34. Brass AL, Huang IC, Benita Y, John SP, Krishnan MN, Feeley EM, Ryan BJ, Weyer JL, van der Weyden L, Fikrig E, Adams DJ, Xavier RJ, Farzan M, Elledge SJ. 2009. The IFITM proteins mediate cellular resistance to influenza A H1N1 virus, West Nile virus, and dengue virus. Cell 139: 1243-54. PMC2824905.
  35. Duan Z, Choy E, Nielsen GP, Rosenberg A, Iafrate J, Yang C, Schwab J, Mankin H, Xavier R, Hornicek FJ. 2010. Differential expression of microRNA (miRNA) in chordoma reveals a role for miRNA-1 in Met expression. J Orthop Res 28: 746-52.
  36. Imielinski M, Baldassano RN, Griffiths A, Russell RK, Annese V, et al. 2009. Common variants at five new loci associated with early-onset inflammatory bowel disease. Nat Genet 41: 1335-40.
  37. Maslowski KM, Vieira AT, Ng A, Kranich J, Sierro F, Yu D, Schilter HC, Rolph MS, Mackay F, Artis D, Xavier RJ, Teixeira MM, Mackay CR. 2009. Regulation of inflammatory responses by gut microbiota and chemoattractant receptor GPR43. Nature 461: 1282-6.
  38. Lapaquette P, Glasser AL, Huett A, Xavier RJ, Darfeuille-Michaud A. 2010. Crohn's disease-associated adherent-invasive E. coli are selectively favoured by impaired autophagy to replicate intracellularly. Cell Microbiol 12: 99-113.
  39. Li Q, Brass AL, Ng A, Hu Z, Xavier RJ, Liang TJ, Elledge SJ. 2009. A genome-wide genetic screen for host factors required for hepatitis C virus propagation. Proc Natl Acad Sci U S A 106: 16410-5. PMC2752535.
  40. Raychaudhuri S, Plenge RM, Rossin EJ, Ng AC, Purcell SM, Sklar P, Scolnick EM, Xavier RJ, Altshuler D, Daly MJ. 2009. Identifying relationships among genomic disease regions: predicting genes at pathogenic SNP associations and rare deletions. PLoS Genet 5: e1000534. PMC2694358.
  41. Huett A and Xavier R. 2009. Building complex biological networks based upon model organisms: mapping the human autophagy interactome via a hybrid yeast-human protein interaction network. Autophagy 5: 884-6.
  42. Benita Y, Kikuchi H, Smith AD, Zhang MQ, Chung DC, Xavier RJ. 2009. An integrative genomics approach identifies Hypoxia Inducible Factor-1 (HIF-1)-target genes that form the core response to hypoxia. Nucleic Acids Res 37: 4587-602. PMC2724271.
  43. Huett A, Leong JM, Podolsky DK, Xavier RJ. 2009. The cytoskeletal scaffold Shank3 is recruited to pathogen-induced actin rearrangements. Exp Cell Res 315: 2001-11. PMC2693461.
  44. Huett A, Ng A, Cao Z, Kuballa P, Komatsu M, Daly MJ, Podolsky DK, Xavier RJ. 2009. A novel hybrid yeast-human network analysis reveals an essential role for FNBP1L in antibacterial autophagy. J Immunol 182: 4917-30. PMC2752416.
  45. Tai AW, Benita Y, Peng LF, Kim SS, Sakamoto N, Xavier RJ, Chung RT. 2009. A functional genomic screen identifies cellular cofactors of hepatitis C virus replication. Cell Host Microbe 5: 298-307. PMC2756022.
  46. Stephenson LM, Miller BC, Ng A, Eisenberg J, Zhao Z, Cadwell K, Graham DB, Mizushima NN, Xavier R, Virgin HW, Swat W. 2009. Identification of Atg5-dependent transcriptional changes and increases in mitochondrial mass in Atg5-deficient T lymphocytes. Autophagy 5: 625-35.
  47. McCarroll SA, Huett A, Kuballa P, Chilewski SD, Landry A, Goyette P, Zody MC, Hall JL, Brant SR, Cho JH, Duerr RH, Silverberg MS, Taylor KD, Rioux JD, Altshuler D, Daly MJ, Xavier RJ. 2008. Deletion polymorphism upstream of IRGM associated with altered IRGM expression and Crohn's disease. Nat Genet 40: 1107-12. PMC2731799.
  48. Medoff BD, Sandall BP, Landry A, Nagahama K, Mizoguchi A, Luster AD, Xavier RJ. 2009. Differential requirement for CARMA1 in agonist-selected T-cell development. Eur J Immunol 39: 78-84. PMC2747028.
  49. Hitomi J, Christofferson DE, Ng A, Yao J, Degterev A, Xavier RJ, Yuan J. 2008. Identification of a molecular signaling network that regulates a cellular necrotic cell death pathway. Cell 135: 1311-23. PMC2621059.
  50. Zhou D, Medoff BD, Chen L, Li L, Zhang XF, Praskova M, Liu M, Landry A, Blumberg RS, Boussiotis VA, Xavier R, Avruch J. 2008. The Nore1B/Mst1 complex restrains antigen receptor-induced proliferation of naive T cells. Proc Natl Acad Sci U S A 105: 20321-6. PMC2600581.
  51. Imamura T, Kikuchi H, Herraiz MT, Park DY, Mizukami Y, Mino-Kenduson M, Lynch MP, Rueda BR, Benita Y, Xavier RJ, Chung DC. 2009. HIF-1alpha and HIF-2alpha have divergent roles in colon cancer. Int J Cancer 124: 763-71. PMC2682346.
  52. Huett A, McCarroll SA, Daly MJ, Xavier RJ. 2009. On the level: IRGM gene function is all about expression. Autophagy 5: 96-9. PMC3204672.
  53. Irazoqui JE, Ng A, Xavier RJ, Ausubel FM. 2008. Role for beta-catenin and HOX transcription factors in Caenorhabditis elegans and mammalian host epithelial-pathogen interactions. Proc Natl Acad Sci U S A 105: 17469-74. PMC2582251.
  54. Kuballa P, Huett A, Rioux JD, Daly MJ, Xavier RJ. 2008. Impaired autophagy of an intracellular pathogen induced by a Crohn's disease associated ATG16L1 variant. PLoS One 3: e3391. PMC2566595.
  55. Cadwell K, Liu JY, Brown SL, Miyoshi H, Loh J, Lennerz JK, Kishi C, Kc W, Carrero JA, Hunt S, Stone CD, Brunt EM, Xavier RJ, Sleckman BP, Li E, Mizushima N, Stappenbeck TS, Virgin HWt. 2008. A key role for autophagy and the autophagy gene Atg16l1 in mouse and human intestinal Paneth cells. Nature 456: 259-63. PMC2695978.
  56. Medoff BD, Landry AL, Wittbold KA, Sandall BP, Derby MC, Cao Z, Adams JC, Xavier RJ. 2009. CARMA3 mediates lysophosphatidic acid-stimulated cytokine secretion by bronchial epithelial cells. Am J Respir Cell Mol Biol 40: 286-94. PMC2645526.
  57. Krishnan MN, Ng A, Sukumaran B, Gilfoy FD, Uchil PD, Sultana H, Brass AL, Adametz R, Tsui M, Qian F, Montgomery RR, Lev S, Mason PW, Koski RA, Elledge SJ, Xavier RJ, Agaisse H, Fikrig E. 2008. RNA interference screen for human genes associated with West Nile virus infection. Nature 455: 242-5. PMC3136529.
  58. Fujiki K, Duerr EM, Kikuchi H, Ng A, Xavier RJ, Mizukami Y, Imamura T, Kulke MH, Chung DC. 2008. Hoxc6 is overexpressed in gastrointestinal carcinoids and interacts with JunD to regulate tumor growth. Gastroenterology 135: 907-16, 916 e1-2.
  59. Friedman CS, O'Donnell MA, Legarda-Addison D, Ng A, Cardenas WB, Yount JS, Moran TM, Basler CF, Komuro A, Horvath CM, Xavier R, Ting AT. 2008. The tumour suppressor CYLD is a negative regulator of RIG-I-mediated antiviral response. EMBO Rep 9: 930-6. PMC2529351.
  60. Barrett JC, Hansoul S, Nicolae DL, Cho JH, Duerr RH, et al. 2008. Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease. Nat Genet 40: 955-62. PMC2574810.
  61. Tamehiro N, Zhou S, Okuhira K, Benita Y, Brown CE, Zhuang DZ, Latz E, Hornemann T, von Eckardstein A, Xavier RJ, Freeman MW, Fitzgerald ML. 2008. SPTLC1 binds ABCA1 to negatively regulate trafficking and cholesterol efflux activity of the transporter. Biochemistry 47: 6138-47. PMC2504083.
  62. Duerr EM, Mizukami Y, Ng A, Xavier RJ, Kikuchi H, Deshpande V, Warshaw AL, Glickman J, Kulke MH, Chung DC. 2008. Defining molecular classifications and targets in gastroenteropancreatic neuroendocrine tumors through DNA microarray analysis. Endocr Relat Cancer 15: 243-56.
  63. Yagi T, Giallourakis C, Mohanty S, Scheidig C, Shen J, Zheng H, Xavier RJ, Shaw AC. 2008. Defective signal transduction in B lymphocytes lacking presenilin proteins. Proc Natl Acad Sci U S A 105: 979-84. PMC2242696.
  64. Brass AL, Dykxhoorn DM, Benita Y, Yan N, Engelman A, Xavier RJ, Lieberman J, Elledge SJ. 2008. Identification of host proteins required for HIV infection through a functional genomic screen. Science 319: 921-6.
  65. Sugimoto K, Ogawa A, Mizoguchi E, Shimomura Y, Andoh A, Bhan AK, Blumberg RS, Xavier RJ, Mizoguchi A. 2008. IL-22 ameliorates intestinal inflammation in a mouse model of ulcerative colitis. J Clin Invest 118: 534-44. PMC2157567.
  66. Cao Z, Huett A, Kuballa P, Giallourakis C, Xavier RJ. 2008. DLG1 is an anchor for the E3 ligase MARCH2 at sites of cell-cell contact. Cell Signal 20: 73-82. PMC2257480.
  67. Shibolet O, Giallourakis C, Rosenberg I, Mueller T, Xavier RJ, Podolsky DK. 2007. AKAP13, a RhoA GTPase-specific guanine exchange factor, is a novel regulator of TLR2 signaling. J Biol Chem 282: 35308-17.
  68. Cotta-de-Almeida V, Westerberg L, Maillard MH, Onaldi D, Wachtel H, Meelu P, Chung UI, Xavier R, Alt FW, Snapper SB. 2007. Wiskott Aldrich syndrome protein (WASP) and N-WASP are critical for T cell development. Proc Natl Acad Sci U S A 104: 15424-9. PMC2000553.
  69. Stephenson LM, Sammut B, Graham DB, Chan-Wang J, Brim KL, Huett AS, Miletic AV, Kloeppel T, Landry A, Xavier R, Swat W. 2007. DLGH1 is a negative regulator of T-lymphocyte proliferation. Mol Cell Biol 27: 7574-81. PMC2169038.
  70. Rioux JD, Xavier RJ, Taylor KD, Silverberg MS, Goyette P, et al. 2007. Genome-wide association study identifies new susceptibility loci for Crohn disease and implicates autophagy in disease pathogenesis. Nat Genet 39: 596-604. PMC2757939.
  71. Mahoney ZX, Sammut B, Xavier RJ, Cunningham J, Go G, Brim KL, Stappenbeck TS, Miner JH, Swat W. 2006. Discs-large homolog 1 regulates smooth muscle orientation in the mouse ureter. Proc Natl Acad Sci U S A 103: 19872-7. PMC1750896.
  72. Miletic AV, Graham DB, Montgrain V, Fujikawa K, Kloeppel T, Brim K, Weaver B, Schreiber R, Xavier R, Swat W. 2007. Vav proteins control MyD88-dependent oxidative burst. Blood 109: 3360-8. PMC1852252.
  73. Fitzgerald ML, Xavier R, Haley KJ, Welti R, Goss JL, Brown CE, Zhuang DZ, Bell SA, Lu N, McKee M, Seed B, Freeman MW. 2007. ABCA3 inactivation in mice causes respiratory failure, loss of pulmonary surfactant, and depletion of lung phosphatidylglycerol. J Lipid Res 48: 621-32.
  74. Ishiguro K, Ando T, Goto H, Xavier R. 2007. Bcl10 is phosphorylated on Ser138 by Ca2+/calmodulin-dependent protein kinase II. Mol Immunol 44: 2095-100.
  75. Yamamoto-Furusho JK, Barnich N, Xavier R, Hisamatsu T, Podolsky DK. 2006. Centaurin beta1 down-regulates nucleotide-binding oligomerization domains 1- and 2-dependent NF-kappaB activation. J Biol Chem 281: 36060-70.
  76. Ishiguro K, Ando T, Maeda O, Hasegawa M, Kadomatsu K, Ohmiya N, Niwa Y, Xavier R, Goto H. 2006. Paeonol attenuates TNBS-induced colitis by inhibiting NF-kappaB and STAT1 transactivation. Toxicol Appl Pharmacol 217: 35-42.
  77. Liu SM, Xavier R, Good KL, Chtanova T, Newton R, Sisavanh M, Zimmer S, Deng C, Silva DG, Frost MJ, Tangye SG, Rolph MS, Mackay CR. 2006. Immune cell transcriptome datasets reveal novel leukocyte subset-specific genes and genes associated with allergic processes. J Allergy Clin Immunol 118: 496-503.
  78. Giallourakis C, Cao Z, Green T, Wachtel H, Xie X, Lopez-Illasaca M, Daly M, Rioux J, Xavier R. 2006. A molecular-properties-based approach to understanding PDZ domain proteins and PDZ ligands. Genome Res 16: 1056-72. PMC1524865.
  79. Ishiguro K, Green T, Rapley J, Wachtel H, Giallourakis C, Landry A, Cao Z, Lu N, Takafumi A, Goto H, Daly MJ, Xavier RJ. 2006. Ca2+/calmodulin-dependent protein kinase II is a modulator of CARMA1-mediated NF-kappaB activation. Mol Cell Biol 26: 5497-508. PMC1592706.
  80. Medoff BD, Seed B, Jackobek R, Zora J, Yang Y, Luster AD, Xavier R. 2006. CARMA1 is critical for the development of allergic airway inflammation in a murine model of asthma. J Immunol 176: 7272-7.
  81. Ishiguro K, Avruch J, Landry A, Qin S, Ando T, Goto H, Xavier R. 2006. Nore1B regulates TCR signaling via Ras and Carma1. Cell Signal 18: 1647-54. PMC3204664.
  82. Barnich N, Aguirre JE, Reinecker HC, Xavier R, Podolsky DK. 2005. Membrane recruitment of NOD2 in intestinal epithelial cells is essential for nuclear factor-{kappa}B activation in muramyl dipeptide recognition. J Cell Biol 170: 21-6. PMC2171381.
  83. Barnich N, Hisamatsu T, Aguirre JE, Xavier R, Reinecker HC, Podolsky DK. 2005. GRIM-19 interacts with nucleotide oligomerization domain 2 and serves as downstream effector of anti-bacterial function in intestinal epithelial cells. J Biol Chem 280: 19021-6.
  84. Lopez-Ilasaca MA, Bernabe-Ortiz JC, Na SY, Dzau VJ, Xavier RJ. 2005. Bioluminescence resonance energy transfer identify scaffold protein CNK1 interactions in intact cells. FEBS Lett 579: 648-54.
  85. Ishiguro K, Cao Z, Ilasca ML, Ando T, Xavier R. 2004. Wave2 activates serum response element via its VCA region and functions downstream of Rac. Exp Cell Res 301: 331-7.
  86. Xavier R, Rabizadeh S, Ishiguro K, Andre N, Ortiz JB, Wachtel H, Morris DG, Lopez-Ilasaca M, Shaw AC, Swat W, Seed B. 2004. Discs large (Dlg1) complexes in lymphocyte activation. J Cell Biol 166: 173-8. PMC2172307.
  87. Rabizadeh S, Xavier RJ, Ishiguro K, Bernabeortiz J, Lopez-Ilasaca M, Khokhlatchev A, Mollahan P, Pfeifer GP, Avruch J, Seed B. 2004. The scaffold protein CNK1 interacts with the tumor suppressor RASSF1A and augments RASSF1A-induced cell death. J Biol Chem 279: 29247-54.
  88. Beck PL, Wong JF, Li Y, Swaminathan S, Xavier RJ, Devaney KL, Podolsky DK. 2004. Chemotherapy- and radiotherapy-induced intestinal damage is regulated by intestinal trefoil factor. Gastroenterology 126: 796-808.
  89. Beck PL, Xavier R, Wong J, Ezedi I, Mashimo H, Mizoguchi A, Mizoguchi E, Bhan AK, Podolsky DK. 2004. Paradoxical roles of different nitric oxide synthase isoforms in colonic injury. Am J Physiol Gastrointest Liver Physiol 286: G137-47.
  90. Ishiguro K and Xavier R. 2004. Homer-3 regulates activation of serum response element in T cells via its EVH1 domain. Blood 103: 2248-56.
  91. Mizoguchi E, Xavier RJ, Reinecker HC, Uchino H, Bhan AK, Podolsky DK, Mizoguchi A. 2003. Colonic epithelial functional phenotype varies with type and phase of experimental colitis. Gastroenterology 125: 148-61.
  92. Swat W, Xavier R, Mizoguchi A, Mizoguchi E, Fredericks J, Fujikawa K, Bhan AK, Alt FW. 2003. Essential role for Vav1 in activation, but not development, of gammadelta T cells. Int Immunol 15: 215-21.
  93. Beck PL, Rosenberg IM, Xavier RJ, Koh T, Wong JF, Podolsky DK. 2003. Transforming growth factor-beta mediates intestinal healing and susceptibility to injury in vitro and in vivo through epithelial cells. Am J Pathol 162: 597-608. PMC1851153.
  94. Schiffmann R, Mankin H, Dambrosia JM, Xavier RJ, Kreps C, Hill SC, Barton NW, Rosenthal DI. 2002. Decreased bone density in splenectomized Gaucher patients receiving enzyme replacement therapy. Blood Cells Mol Dis 28: 288-96.
  95. Khokhlatchev A, Rabizadeh S, Xavier R, Nedwidek M, Chen T, Zhang XF, Seed B, Avruch J. 2002. Identification of a novel Ras-regulated proapoptotic pathway. Curr Biol 12: 253-65.
  96. Mizoguchi E, Mizoguchi A, Takedatsu H, Cario E, de Jong YP, Ooi CJ, Xavier RJ, Terhorst C, Podolsky DK, Bhan AK. 2002. Role of tumor necrosis factor receptor 2 (TNFR2) in colonic epithelial hyperplasia and chronic intestinal inflammation in mice. Gastroenterology 122: 134-44.
  97. Colucci R, Fleming JV, Xavier R, Wang TC. 2001. L-histidine decarboxylase decreases its own transcription through downregulation of ERK activity. Am J Physiol Gastrointest Liver Physiol 281: G1081-91.
  98. Chung RT, He W, Saquib A, Contreras AM, Xavier RJ, Chawla A, Wang TC, Schmidt EV. 2001. Hepatitis C virus replication is directly inhibited by IFN-alpha in a full-length binary expression system. Proc Natl Acad Sci U S A 98: 9847-52. PMC55541.
  99. Mankin HJ, Rosenthal DI, Xavier R. 2001. Gaucher disease. New approaches to an ancient disease. J Bone Joint Surg Am 83-A: 748-62.
  100. Merscher S, Funke B, Epstein JA, Heyer J, Puech A, et al. 2001. TBX1 is responsible for cardiovascular defects in velo-cardio-facial/DiGeorge syndrome. Cell 104: 619-29.
  101. Beck PL, Xavier R, Lu N, Nanda NN, Dinauer M, Podolsky DK, Seed B. 2000. Mechanisms of NSAID-induced gastrointestinal injury defined using mutant mice. Gastroenterology 119: 699-705.
  102. Muehlhoefer A, Saubermann LJ, Gu X, Luedtke-Heckenkamp K, Xavier R, Blumberg RS, Podolsky DK, MacDermott RP, Reinecker HC. 2000. Fractalkine is an epithelial and endothelial cell-derived chemoattractant for intraepithelial lymphocytes in the small intestinal mucosa. J Immunol 164: 3368-76.
  103. Itoh H, Beck PL, Inoue N, Xavier R, Podolsky DK. 1999. A paradoxical reduction in susceptibility to colonic injury upon targeted transgenic ablation of goblet cells. J Clin Invest 104: 1539-47. PMC409855.
  104. Fukumura D, Xavier R, Sugiura T, Chen Y, Park EC, Lu N, Selig M, Nielsen G, Taksir T, Jain RK, Seed B. 1998. Tumor induction of VEGF promoter activity in stromal cells. Cell 94: 715-25.
  105. Hocker M, Rosenberg I, Xavier R, Henihan RJ, Wiedenmann B, Rosewicz S, Podolsky DK, Wang TC. 1998. Oxidative stress activates the human histidine decarboxylase promoter in AGS gastric cancer cells. J Biol Chem 273: 23046-54.
  106. Xavier R, Brennan T, Li Q, McCormack C, Seed B. 1998. Membrane compartmentation is required for efficient T cell activation. Immunity 8: 723-32.
  107. Swat W, Fujikawa K, Ganiatsas S, Yang D, Xavier RJ, Harris NL, Davidson L, Ferrini R, Davis RJ, Labow MA, Flavell RA, Zon LI, Alt FW. 1998. SEK1/MKK4 is required for maintenance of a normal peripheral lymphoid compartment but not for lymphocyte development. Immunity 8: 625-34.
  108. Liang TJ, Reid AE, Xavier R, Cardiff RD, Wang TC. 1996. Transgenic expression of tpr-met oncogene leads to development of mammary hyperplasia and tumors. J Clin Invest 97: 2872-7. PMC507382.
  109. Greenberg S, Chang P, Wang DC, Xavier R, Seed B. 1996. Clustered syk tyrosine kinase domains trigger phagocytosis. Proc Natl Acad Sci U S A 93: 1103-7. PMC40038.

Reviews, Chapters, and Editorials

  1. Kuballa P, Nolte WM, Castoreno AB, Xavier RJ. 2012. Autophagy and the immune system. Annu Rev Immunol 30: 611-46
  2. Khor B, Gardet A, Xavier RJ. 2011. Genetics and pathogenesis of inflammatory bowel disease. Nature 474: 307-17
  3. Stappenbeck TS, Rioux JD, Mizoguchi A, Saitoh T, Huett A, Darfeuille-Michaud A, Wileman T, Mizushima N, Carding S, Akira S, Parkes M, Xavier RJ. 2011. Crohn disease: a current perspective on genetics, autophagy and immunity. Autophagy 7: 355-74
  4. Bekpen C, Xavier RJ, Eichler EE. 2010. Human IRGM gene "to be or not to be". Semin Immunopathol 32: 437-44
  5. Huett A, Goel G, Xavier RJ. 2010. A systems biology viewpoint on autophagy in health and disease. Curr Opin Gastroenterol 26: 302-9
  6. Huett A, Xavier RJ. 2010. Autophagy at the gut interface: mucosal responses to stress and the consequences for inflammatory bowel diseases. Inflamm Bowel Dis 16: 152-74
  7. Heath RJ, Xavier RJ. 2009. Autophagy, immunity and human disease. Curr Opin Gastroenterol 25: 512-20
  8. Avruch J, Xavier R, Bardeesy N, Zhang XF, Praskova M, Zhou D, Xia F. 2009. Rassf family of tumor suppressor polypeptides. J Biol Chem 284: 11001-5
  9. Xavier RJ, Rioux JD. 2008. Genome-wide association studies: a new window into immune-mediated diseases. Nat Rev Immunol 8: 631-43
  10. Xavier RJ, Huett A, Rioux JD. 2008. Autophagy as an important process in gut homeostasis and Crohn's disease pathogenesis. Gut 57: 717-20
  11. Seed B, Xavier R. 2008. Spinophilin and the immune synapse. J Cell Biol 181: 181-3
  12. Huett A, Xavier RJ. 2008. Neither hide nor hair: the difficulty of identifying useful disease biomarkers. Gastroenterology 134: 2164-8
  13. Huett A, Xavier R. 2008. SNPping away at the pathogenesis of Crohn's disease. Inflamm Bowel Dis 14: 136-7
  14. Xavier RJ, Podolsky DK. 2007. Unravelling the pathogenesis of inflammatory bowel disease. Nature 448: 427-34
  15. Huett A, Benita Y, Xavier R J. The role of the calmodulin-dependent protein kinase II (CaMKII) in the regulation of T lymphocyte development and activation [Chapter]. In: Lymphocyte Activation and Signal Transduction. Research Signpost
  16. Goyette P, Labbe C, Trinh TT, Xavier RJ, Rioux JD. 2007. Molecular pathogenesis of inflammatory bowel disease: genotypes, phenotypes and personalized medicine. Ann Med 39: 177-99
  17. Landry A, Xavier R. 2006. Isolation and analysis of lipid rafts in cell-cell interactions. Methods Mol Biol 341: 251-82
  18. Xavier R, Seed B. 2005. PDZ domains and the politics of polarity in lymphocytes. Immunity 22: 655-6
  19. Xavier R, Podolsky DK. 2005. Commensal flora: wolf in sheep's clothing. Gastroenterology 128: 1122-6
  20. Chawla N, Andre N, Choi M, Bernabe-Ortiz J, Xavier R. 2001. An update on lymphocyte activation and signal transduction in inflammation. 7th International Symposium on Inflammatory Bowel Diseases. 11-30.
  21. Ting A, Lichtenthaler S, Xavier R, Na SY, Rabizadeh S, Holmes T, Seed B. 2005. Large-scale screens for cDNAs with in vivo activity. Novartis Found Symp 267: 219-29; discussion 29-30
  22. Xavier RJ, Podolsky DK. 2000. Microbiology. How to get along--friendly microbes in a hostile world. Science 289: 1483-4
  23. Xavier R, Seed B. 1999. Membrane compartmentation and the response to antigen. Curr Opin Immunol 11: 265-9
  24. Lown B, Bukachi F, Xavier R. 1998. Health information in the developing world. Lancet 352 Suppl 2: SII34-8
  25. Xavier RJ, Podolsky DK. 1995. Addressing lymphocytes for mucosal delivery in IBD. Inflamm Bowel Dis 11(4):343-344
  26. Mullaney J, Xavier R. 1995. Satellife: Building an electronic health network in the developing world. Technology and Informatics 23:265-275.
  27. Rachmilewitz D, Stamler J, Karmeli F, Loscalzo J, Xavier RJ, Podolsky DK. 1994. Role of nitric oxide in the pathogenesis of IBD.Rachmilewitz D, ed. Inflamm Bowel Dis 1:82-90.
  28. Xavier RJ, Mann J, Tarantola DJ, Netter TW. 1992. AIDS and tuberculosis: A dangerous synergy [Chapter]. In: AIDS in the world. Harvard University Press, 148-163.
  29. Bigger RJ, Xavier RJ. 1992. AIDS and cancer [Chapter]. In: AIDS in the World. Harvard University Press, 134-143.
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